The TSET Legacy Grant (opening April 15, 2025) is a one-time, historic funding opportunity designed to address Oklahoma’s leading causes of death—cancer and cardiovascular disease. With a $150 million investment, TSET is funding large-scale, transformational projects that will improve rural health, healthcare access, prevention and data-driven solutions across the state.

The TSET Legacy Grant is more than just funding—it’s an investment in Oklahoma’s future. By supporting projects that tackle the root causes of chronic disease, we are helping to build a healthier, stronger state for generations to come.

This initiative will have broad, lasting impact, particularly in rural and underserved communities, and will help drive data-informed solutions to improve health outcomes statewide.

On April 15, the Request for Applications guidance document will be released which will provide all of the funding opportunity details and how to submit applications. A webinar will also take place that day to explain the grant in greater detail.

TSET Legacy Grants will have a minimum requirement on applications of at least a $3 million per project. Projects must be a minimum of 1 year and may not exceed 3 years in duration.

TSET is seeking grants which will make major health impacts for Oklahomans in areas such as: 

• Rural Health
• Healthcare Access improvement
• Data Gaps
• Early Prevention
• Quality of Life Improvements 

Through grant opportunities that are:

• Time limited, scaleable
• Project oriented and launch-ready
• Sustainable, independent of TSET funding at the end of the grant term

TSET seeks to work with qualified organizations that:

• Demonstrate the ability to spend reimbursable grant dollars within the allotted time frame
• Utilize evidence-based or promising practices
• Will have wide reach/audience
• Can support TSET goals of awareness, statewide presence

Eligible Organizations include: 

• Public institutions of higher education (research and regional universities and colleges) 
• State agencies 
• Not-for profit organizations
• Public entities such as county/local government, public school districts
• Tribal entities

Grants are paid on a reimbursement basis, so organizations must demonstrate the capacity to sustain programmatic work and manage funds for up to six months while awaiting reimbursement.

Have Questions?

For specific questions regarding TSET Legacy Grants, please fill out this FORM. To ensure fairness in the Q&A process, we will collect all questions of this type and post them below according to the RFA answer posting dates. The first set of responses will be posted on April 30, 2025.