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Media Release

OPCIE, OSU collaborate to develop groundbreaking visual sensor to trace infectious diseases at the point-of-needs

March 16, 2022

STILLWATER — The Oklahoma Pandemic Center for Innovation and Excellence (OPCIE) is collaborating with Oklahoma State University (OSU) to develop an affordable, accurate and efficient visual molecular diagnostic tool to trace infectious diseases.

“Current methods used to trace infectious diseases are expensive, time-consuming and often require highly-trained personnel and sophisticated facilities,” said Dr. Pravin Mishra, Chief Operating Officer of the OPCIE. “This diagnostic tool offers a solution to those limitations and improves accuracy. Both are critical to combatting the ongoing COVID-19 pandemic and preparing to respond to future public health threats.”

A multidisciplinary team of faculty (Dr. Yolanda Vasquez, Dr. Joshua Ramsey, Dr. Sathya Aakur, Dr. Steven Hartson, Dr. Lan Zhu, and Dr. Sadagopan Krishnan) and graduate students at OSU are working closely with staff at the OPCIE to develop the tool — a nano-bioconjugation-based, visual colorimetric multiplex sensor to trace infectious diseases at the point-of-needs. The sensor has a color intensity profile that provides a visual distinction between variants of infectious diseases, similar to pH indicator paper.

By targeting a panel of target biomarkers in biofluids, the sensor will accurately capture infectious disease-specific signals, helping avoid the false positive and negative detection rates often associated with diagnostic biological sensors and assays. This advanced diagnostic tool will also broadly facilitate early disease diagnosis, prognosis and post-occurrence conditions.

“It is critical that we invest in the development of cutting-edge technology in molecular diagnostics as part of the OPCIE’s mission to research and respond to public health threats,” said Elizabeth Pollard, Secretary of Science and Innovation. “By operating in partnership with the bright minds at OSU, we will create a product that will help change the landscape of public health response globally.”

“This is an invaluable opportunity for students at OSU to get hands-on experience in biomedical research in collaboration with the top talent and state-of-the-art equipment at the OPCIE,” said Dr. Sadagopan Krishnan, Associate Professor in the Department of Chemistry at OSU. “Our research team is composed of highly talented and dedicated dynamic graduate and undergraduate students to aid in the development of the above described groundbreaking technology.”

Media Release

OPCIE announces new collaboration with Oklahoma Conservation Commission

January 26, 2022

Innovative regenerative soil practices will result in improved agricultural outcomes

STILLWATER, OKLA. — The Oklahoma Pandemic Center for Innovation and Excellence (OPCIE) announced today an exciting new partnership with the Oklahoma Conservation Commission (OCC). The collaboration will feature the development of Soil Health Management Systems, an invaluable tool that will help ensure Oklahoma farmers and ranchers have healthy soil, plants and animals for generations to come.

“We’re excited to enter this collaboration with the OCC and establish an innovative standard for agricultural practices in the state of Oklahoma,” said Elizabeth Pollard, Secretary of Science and Innovation. “As a largely rural and agricultural state, we have an opportunity to become a leader in regenerative soil research and continue to position Oklahoma as a top ten state.”

This comprehensive management system will allow farmers to monitor soil, air, plant and water health quality. Using its web and mobile-based resource applications, they can review the data and make informed decisions to improve their soil quality, increase profitability and provide quality products to consumers throughout the state and nation.

“Studying soil health practices and regenerative agriculture can greatly improve the quality of both crops and animals,” said Dr. Pravin Mishra, Chief Operating Officer at the OPCIE.

The OPCIE has adopted a One Health approach to public health, which recognizes that the health of people is closely connected to the health of animals and the environment. Using this approach, the OPCIE sets a new standard for promoting, preserving and responding to public health.

“Everything we do at the OPCIE is centered around our One Health approach, and we believe this partnership with the OCC will help bring us closer to fulfilling our vision of improving the health of humans and animals by studying the health of our soil and environment,” said Dr. Mishra.

Studying soils and biofortification can also play a critical role in understanding how infectious diseases, such as COVID-19, are transmitted. By entering into this partnership with the OCC, researchers can begin exploring links between soil health, animal health, human health and pandemic prevention.

“Our team has decades of experience working on initiatives to reduce soil erosion, prevent flooding and improve the quality of stream water, which all directly impact the health and wellbeing of Oklahomans,” said Trey Lam, Executive Director of the OCC. “We’re excited to share this partnership with the OPCIE and leverage our joint expertise in human, animal and environmental health to provide innovative solutions to our local agricultural communities, while continuing to preserve the health of Oklahomans.” 

Media Release

Oklahoma Pandemic Center for Innovation and Excellence hires new chief operating officer, enters national collaboration

STILLWATER, OKLA. — Prairie One Solutions announced yesterday the hiring of Dr. Pravin Mishra as chief operating officer at the Oklahoma Pandemic Center for Innovation and Excellence (OPCIE). 

“I am thrilled to serve in this role and to begin contributing to innovative advancements for the state of Oklahoma,” said Dr. Mishra. “The OPCIE is a state-of-the-art facility and I am looking forward to collaborating with the local team and national partners to advance our capabilities and fulfill our visionary mission that will become the One Health Park Campus.”

Prior to joining the OPCIE, Dr. Mishra served as the director of clinical translational science resources at the Ohio State University Comprehensive Cancer Center, where he oversaw laboratory operations and led innovative discovery efforts in precision medicine and oncology. 

Dr. Mishra earned his Ph.D. in molecular medicine and oncology from George Washington University and has been cited in numerous studies involving oncology, stem cells, cancer genomics, drug discovery and developmental therapeutics. 

He spent four years (2010-2014) training at the National Institutes of Health (NIH) working on next-generation sequencing, which led to the discovery of signature biomarkers that can predict late-stage melanoma patient survival. He is a recipient of the National Cancer Institute’s Director’s Award, in which he was nominated by Nobel Prize Winner Dr. Harold Varmus. 

“Dr. Mishra has an impressive and extensive background in critical genomic scientific research,” said Elizabeth Pollard, Secretary of Science and Innovation. “We are excited to have a highly respected member of the scientific community join the OPCIE and move us toward our vision of establishing a nationally competitive lab. I’m confident that Dr. Mishra’s leadership and expertise wil be an integral part of the OPCIE’s growth and continued success as we work to construct the One Health Park Campus.”

“Dr. Mishra brings more than 15 years of experience in healthcare research and innovation to the OPCIE,” said Kenneth Sewell, president of Prairie One Solutions. “With his expertise in leading breakthrough research and laboratory management, he is a great fit to lead us toward our future vision for the OPCIE.”

Collaboration Agreement with Connected DMV

OPCIE recently entered into a collaboration agreement with Connected DMV (an acronym for D.C./Maryland/Virginia).  Connected DMV is a Virginia-based organization launched in 2019 in collaboration with the Greater Washington Board of Trade, Metropolitan Washington Council of Governments, Consortium of Universities of the Washington Metropolitan Area, Washington Metropolitan Area Transportation Authority, and Joint Force Headquarters National Capital Region to fulfill the need for a long-term, robust, and response mechanism to deliver public-private regional initiatives at scale. With the onset of the coronavirus pandemic, Connected DMV began working with other partners in their region on a pandemic prevention and biodefense initiative.  They have now partnered with OPCIE as well, linking the D.C./Maryland/Virginia regional efforts with the efforts in Oklahoma.

“As we are all painfully aware, pandemics cross geographical boundaries rapidly,” Sewell said.  “Our partnership with Connected DMV links the OPCIE’s One Health approach and capabilities with the biohealth technology innovators in the broader Washington D.C. region. Collaborations like this are both strategically and politically crucial to reaching our ultimate vision.”

The OPCIE is the first of its kind. A  collaborative, immersive campus located in the heart of the U.S. bringing disruptive science to the fields of human, animal, and environmental health. With innovation at its core, the OPCIE leverages public and private partnerships to bridge the gap between laboratory and clinical practices and creates improved public health responses to the unique needs of rural, urban, and tribal communities. Through its One Health approach, the OPCIE will become a global leader in promoting pandemic awareness and preserving public health. 

To learn more about the OPCIE visit http://oklahoma.gov/OPCIE or follow on TwitterFacebook

 

Last Modified on Mar 17, 2022